Bath centre Kyle Eastmond could miss the start of England's Six Nations campaign with a shoulder injury.
The 25-year-old suffered the problem on Sunday during his club's dramatic victory over Glasgow Warriors in the European Rugby Champions Cup.
Eastmond is due to have a scan to assess the damage, but he remains doubtful for England's trip to Wales for the start of the Six Nations on February 6.
Meanwhile, Saracens fly-half Owen Farrell is also expected to miss the match in Cardiff due to a knee problem.