Lazio vs. Crotone (Friday, 2.00pm)
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European hopefuls Lazio host relegation strugglers Crotone in what will be the first Serie A match played at 3pm (CET) on a Friday in the 21st century.
The Aquile have suffered a dip in form recently, losing their last three matches in all competitions, while Crotone claimed only their fourth victory of the campaign last weekend against Torino.
We say: Lazio 3-1 Crotone
Lazio will be keen to put their troubles of the past fortnight behind them as they hope to stay in contention for a return to European competition next season.
Crotone are fighting for their lives at the bottom, and last weekend's victory will give them belief heading to the capital, but the hosts should have enough quality to claim all three points on Friday.
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Atalanta vs. Spezia (Friday, 7.45pm)
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Atalanta BC will be looking to get back to winning ways and stay in the race for a top-four finish when they host Spezia in Serie A on Friday evening.
The visitors, meanwhile, have accumulated just two points from the last 12 available and have lost their previous two away matches by a 3-0 scoreline.
We say: Atalanta BC 3-0 Spezia
Even though Atalanta will have one eye on their Champions League last-16 second-leg tie against Real Madrid next Tuesday, Gasperini will be keen for his side to secure all three points on Friday and remain in the hunt for a top-four finish.
Spezia have accumulated more points on the road so far this season, but the hosts should have enough quality to claim another comfortable victory at the Gewiss Stadium.