Belgian Pro League 2021-22 Head-to-Head
Top Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Anderlecht | 12 | 6 | 5 | 1 | 29 | 12 | 17 | 23 |
| 2 | Club BruggeBrugge | 12 | 5 | 6 | 1 | 19 | 13 | 6 | 21 |
| 3 | CharleroiCharleroi | 10 | 6 | 0 | 4 | 23 | 15 | 8 | 18 |
| 4 | Cercle BruggeCercle Brugge | 10 | 5 | 1 | 4 | 13 | 12 | 1 | 16 |
| 5 | EupenEupen | 10 | 3 | 2 | 5 | 11 | 20 | -9 | 11 |
| 6 | Beerschot WilrijkBeerschot VA | 10 | 0 | 0 | 10 | 9 | 32 | -23 | 0 |
Bottom Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Union SGUnion SG | 12 | 8 | 1 | 3 | 24 | 9 | 15 | 25 |
| 2 | Royal AntwerpAntwerp | 12 | 6 | 2 | 4 | 17 | 14 | 3 | 20 |
| 3 | Sint-Truiden | 10 | 6 | 1 | 3 | 16 | 11 | 5 | 19 |
| 4 | Zulte WaregemZulte | 10 | 4 | 0 | 6 | 10 | 16 | -6 | 12 |
| 5 | RFC Seraing | 10 | 3 | 0 | 7 | 12 | 17 | -5 | 9 |
| 6 | Standard Liege | 10 | 3 | 0 | 7 | 10 | 22 | -12 | 9 |
