Everton vs. Man Utd (Saturday, 12.30pm)
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Two teams in desperate need of the three points will lock horns for a key Premier League contest on Saturday afternoon, as Everton welcome Manchester United to Goodison Park.
Everton's relegation fears deepened on Wednesday when they lost 3-2 at fellow strugglers Burnley, while Man United saw their top-four hopes take a hit last weekend, dropping points at home to Leicester City.
We say: Everton 1-2 Manchester United
Everton certainly have a result in them at Goodison Park, and they will fancy their chances of causing a damaged Man United team problems on Saturday. That said, Ronaldo's return will boost the Red Devils, and we are expecting a very tight match to swing the way of the 20-time English champions, further deepening Everton's relegation fears at a key period of the campaign.
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> How Manchester United could line up against Everton
> Man United injury, suspension list vs. Everton
Arsenal vs. Brighton (Saturday, 3.00pm)
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Seeking to get their top-four charge right back on track, Arsenal welcome Brighton & Hove Albion to the Emirates Stadium for Saturday's Premier League encounter.
The Gunners were outfought and outclassed in a 3-0 defeat to Crystal Palace on Monday, while Graham Potter's side most recently drew 0-0 with Brighton & Hove Albion.
We say: Arsenal 2-0 Brighton & Hove Albion
Arsenal sure are under pressure to prove that their dire showing at Selhurst Park was just a one-off, and they could hardly have been handed a friendlier fixture to return to winning ways.
Brighton's continued struggles in front of goal are showing no signs of letting up anytime soon, and even with their recent injury blows, Arsenal's young guns should prevail comfortably.
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> How Arsenal could line up against Brighton
> Arsenal injury, suspension list vs. Brighton
Southampton vs. Chelsea (Saturday, 3.00pm)
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Chelsea will aim to avoid a third defeat on the bounce in all competitions when they travel to St Mary's to face Southampton in Saturday's Premier League contest.
Thomas Tuchel's side fell to a 3-1 defeat in the first leg of their Champions League quarter-final to Real Madrid in midweek, while the Saints most recently drew 1-1 with Leeds United.
We say: Southampton 1-3 Chelsea
Chelsea are certainly in a sticky patch both on and off the pitch right now, but their plentiful options for change, penchant for away-day victories and desperate need to respond ahead of the second leg with Real should all work in their favour here.
Keeping the back door shut has been an issue for Southampton recently, and with a key attacking threat in Broja ineligible to face his parent club, we have faith in a freshened-up Blues side to lay down a marker with a convincing return to winning ways.
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> How Chelsea could line up against Southampton
> Chelsea injury, suspension list vs. Southampton
Watford vs. Leeds (Saturday, 3.00pm)
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Two teams battling to remain in the Premier League will lock horns at Vicarage Road on Saturday afternoon, as Watford welcome Leeds United.
Watford are currently 19th in the table, three points behind 17th-placed Everton, while Leeds occupy 16th spot, six points ahead of 18th-placed Burnley, having played two games more than the Clarets.
We say: Watford 1-1 Leeds United
Both sides are in desperate need of the three points at a vital stage of the season, but we are finding it difficult to separate them here. There has not actually been a draw between these two sides since December 2013, but we are predicting a stalemate at Vicarage Road on Saturday afternoon.
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Aston Villa vs. Spurs (Saturday, 5.30pm)
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Tottenham Hotspur will be bidding to make it four Premier League victories in a row when they head to Villa Park on Saturday evening to take on Aston Villa.
Spurs are currently fourth in the table, level on points with fifth-placed Arsenal in the race for a top-four spot, while Villa occupy 11th position, one point behind 10th-placed Leicester City.
We say: Aston Villa 1-2 Tottenham Hotspur
Tottenham are winning a lot of football matches at the moment, and they were excellent going forward in last weekend's 5-1 win over Newcastle. Villa will make it difficult for Conte's side, but we believe that the visitors will have enough quality in the final third to put another huge three points on the board.
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