Tottenham Hotspur attacker Dejan Kulusevski has been ruled out of Sunday's Premier League contest with Newcastle United in North London.

The Juventus loanee has not played since sustaining a hamstring injury during the most recent international break, and his absence was well and truly felt in Wednesday's defeat to Manchester United.

Richarlison also remains on the sidelines with his calf injury, but Antonio Conte's switch to a 3-5-2 did not work as intended at Old Trafford, and a reshuffled 3-4-3 could be on the cards this weekend.

Harry Kane and Son Heung-min will continue in the attack, and they may be joined by Ivan Perisic, who Conte affirmed could play further forward before the loss to Man United.

Lucas Moura's minutes are still being managed carefully following his tendon injury, so Perisic may be given the nod on the left, as Ryan Sessegnon returns to wing-back duties.

Emerson Royal has now served a three-game domestic ban and is in with chance of displacing Matt Doherty, while Rodrigo Bentancur and Pierre-Emile Hojbjerg are expected to line up in midfield, with Yves Bissouma dropping out.

Fred's opener for Man United took a significant deflection off Ben Davies, and the Welshman is at risk of losing his spot to Clement Lenglet as Eric Dier and Cristian Romero hold their spots in front of Hugo Lloris.

Tottenham possible starting lineup: Lloris; Romero, Dier, Lenglet; Emerson, Hojbjerg, Bentancur, Sessegnon; Son, Kane, Perisic