The winner of this semi-final tie will be big favourites to lift the Carling Cup next month.
It is Liverpool who hold the initial advantage, having recorded a 1-0 win at the Etihad Stadium a fortnight ago courtesy of a penalty from Steven Gerrard.
City will make the trip to Anfield without a number of key players, as Vincent Kompany serves the last game of his four-match suspension, while the Toure brothers are on international duty at the Africa Cup of Nations.
Hosts Liverpool are still without Luis Suarez, who is suspended. Andy Carroll is expected to continue in attack, with skipper Gerrard offering support from midfield.
Current form:
Liverpool: DDWLDL
Man City: WDLWWW
Possible lineups:
Liverpool: Reina; Johnson, Agger, Skrtel, Enrique; Downing, Gerrard, Adam, Kuyt; Bellamy, Carroll.
Man City: Hart; Zabaleta, Richards, Lescott, Clichy; Barry, De Jong, Milner; Johnson, Silva, Aguero.
Sports Mole says: 1-1