Arsenal have been drawn a tough fixture against AC Milan in the first knockout round of the Champions League, while Chelsea go head to head with Napoli on the road to Munich.
The London sides went into the draw in Nyon hoping that they could avoid the Italian giants, but Arsene Wenger's side will have to play the Serie A outfit over two legs next year.
Andre Villas-Boas's Chelsea side will have to defeat Napoli in order to progress through the competition, while Barcelona have Bayer Leverkusen to overcome and Jose Mourinho's Real Madrid have a lengthy trip to Russia to play CSKA Moscow.
The Premier League sides will compete the first leg of the contest away, with a potential deciding match being held on home turf over February and March.