Napoli vs. Ajax (Wednesday, 5.45pm)
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Eight days on from their thumping win in Amsterdam, Group A leaders Napoli face Ajax again, as they seek to secure a place in the Champions League knockout stage at Stadio Maradona.
The teams reconvene on Wednesday evening, with the hosts able to assure progress by beating their Dutch counterparts for a second time; the visitors need points to stay in touch with Liverpool.
We say: Napoli 2-1 Ajax
Having now won eight times in a row for the first time in club history, Napoli's confidence could not be higher. However, Ajax still bear the scars from last week and will take care not to make the same mistakes again, so it could be a closer contest this time between two attractive sides.
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Atletico vs. Brugge (Wednesday, 5.45pm)
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Atletico Madrid will be looking for revenge against Club Brugge when they welcome the Belgian giants to Wanda Metropolitano in the Champions League on Wednesday night.
Club Brugge recorded a 2-0 victory when the pair locked horns last week, with the result leaving Carl Hoefkens's side top of Group B on nine points, while Atletico are bottom of the section on three points.
We say: Atletico Madrid 2-1 Club Brugge
Club Brugge have been exceptional in the competition this season, and it would be some result if they managed to triumph on Wednesday night. Atletico have had their problems this season, but it is difficult to back against them at home, and we are predicting a narrow success for Simeone's side here.
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Rangers vs. Liverpool (Wednesday, 8.00pm)
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Rangers will be aiming to get themselves off the mark in this season's Champions League when they host Liverpool on Wednesday, having suffered three straight defeats in Group A.
The Reds, meanwhile, will hope to extend their three-point gap ahead of third-placed Ajax.
We say: Rangers 1-3 Liverpool
We expect Rangers to give Liverpool a much tougher match than the Reds' comfortable 2-0 win at Anfield last week, but the visitors are likely to have too much firepower in the end.
The Gers' necessity to go for the win may play into Klopp's side's hands as, despite their recent defensive issues, they still retain bags of pace and quality in attack.
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> How Liverpool could line up against Rangers
> Liverpool injury, suspension list vs. Rangers
B. Leverkusen vs. Porto (Wednesday, 8.00pm)
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Tied on three points apiece after last week's reverse fixture in Portugal, Group B rivals Bayer Leverkusen and Porto meet again on Wednesday, with progress to the Champions League's last-16 still up for grabs.
While surprise package Club Brugge are currently sprinting off into the distance, both sides join Atletico Madrid six points behind the leaders after Leverkusen lost 2-0 at Estadio Dragao last time out - a result which prompted a change of coach for Die Werkself.
We say: Bayer Leverkusen 2-1 Porto
Revenge could be served lukewarm in Leverkusen, as the hosts will strike back just a week after their defeat at the Dragao. With an exciting new era afoot under highly-rated boss Xabi Alonso, optimism can ignite a performance to lift the hosts back above Porto in the standings.
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Barcelona vs. Inter Milan (Wednesday, 8.00pm)
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Barcelona will be looking to give their Champions League knockout-round hopes a huge boost when they welcome Inter Milan to Camp Nou for a key encounter on Wednesday night.
The Catalan outfit are third in Group C, three points behind second-placed Inter, with the Italian giants recording a 1-0 victory when the two teams locked horns at San Siro last week.
We say: Barcelona 2-1 Inter Milan
There is no downplaying the importance of this match, with Barcelona in desperate need of all three points to boost their knockout hopes. We are expecting this to be a very tight game, with Inter more than capable of picking up a positive result, but Barcelona should just have enough at home to claim a vital win.
> Click here to read our full preview for this match
> How Barcelona could line up against Inter Milan
> Barcelona injury, suspension list vs. Inter Milan
Spurs vs. Frankfurt (Wednesday, 8.00pm)
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Tottenham Hotspur will welcome Eintracht Frankfurt and their masses of supporters to North London on Wednesday for an important matchday four encounter in the UEFA Champions League.
Both clubs sit on four points in Group D with Spurs only currently above their German opponents on goal difference, occupying the second qualifying spot for the last 16.
We say: Tottenham Hotspur 1-0 Eintracht Frankfurt
Frankfurt may have lost heavily at the weekend, but Glasner rested more than a few key starters with one eye on this game, and with those expected to come back in, they surely will put in a more spirited effort.
With defeat being unacceptable and a draw hardly ideal, Spurs must find something to take all three points, and they may just have the individual quality to snatch a result in a group which has produced very few goals so far.
> Click here to read our full preview for this match
> How Spurs could line up against Frankfurt
> Spurs injury, suspension list vs Frankfurt
Sporting Lisbon vs. Marseille (Wednesday, 8.00pm)
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Seeking to pick up a fourth consecutive home victory, Sporting Lisbon go head to head with Marseille to the Estadio Jose Alvalade in Group D of the Champions League on Wednesday.
The Ligue 1 outfit finally got their European campaign underway last week when they comfortably edged out Ruben Amorim's side on home turf and will be looking to continue in the same vein.
We say: Sporting Lisbon 2-1 Marseille
While Marseille will be looking to boost their hopes of a place in the knockout stages with successive victories, they face a Sporting Lisbon side who are on a fine run of form in front of their home fans. We predict the Primeira Liga side, who have won their last three home matches, will build on last weekend's result over Santa Clara and claim a slender victory.
