Sevilla have relieved Eduardo Berizzo of his managerial duties with the Spanish club.
Berizzo, 48, was recently diagnosed with prostate cancer, and underwent successful surgery towards the end of last month.
The Argentine is now on the road to recovery, but has been sacked from his position as head coach of Sevilla just one week after returning to work.
Berizzo, who moved to the Estadio Ramon in the summer after leaving Celta Vigo, led the Spanish club into the last-16 stage of the Champions League, while they are fifth in La Liga after 17 matches of the 2017-18 campaign.
"Sevilla FC's board of directors, who met on the afternoon of Friday the 22nd of December, has taken the decision to dismiss first-team coach, Eduardo Berizzo, on account of the team's poor run of results," read a statement on Sevilla's official website.
"Sevilla FC would like to express its gratitude to Berizzo for his professionalism, the work he has delivered and his treatment of all the members of the club since his arrival. Sevilla FC has already entered into conversations to appoint a new manager, who is expected to join the club after the winter break."
Sevilla will not return to competitive action until they face Cadiz in the Copa del Rey on January 3.