Real Madrid are ready to listen to offers for Isco, according to reports.
The midfielder could be made available in the summer, with Manchester City and Arsenal said to be interested.
Real are looking to land Paul Pogba or Marco Verratti from Paris Saint-Germain, The Mirror claims, and could sell 22-year-old Isco for around £35m to free up some money.
The Spaniard featured in last night's 3-1 win over Malaga, playing the full 90 minutes.
Isco has been in and out of the starting XI for Real, but could start the crunch match against Atletico Madrid next week, with both Luka Modric and Gareth Bale potentially out.