Leicester vs. Liverpool (Saturday, 12.30pm)
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Third hosts fourth in the Premier League on Saturday lunchtime when high-flying Leicester City welcome champions Liverpool to the King Power Stadium.
Three points separate the two sides in the table after 23 games, and the visitors arrive at the King Power looking to bounce back from successive league defeats for the first time under Jurgen Klopp.
We say: Leicester City 1-2 Liverpool
This is another tricky match in a very difficult run for Liverpool - both in terms of form and fixtures - but we are expecting the Reds to come out on top and pick up a much-needed victory.
Leicester have been one of the best sides in the division for almost two full seasons now but Liverpool have always dealt with them well in that time - most notably winning the last two meetings by a 7-0 aggregate scoreline, including a 3-0 triumph in the reverse.
The Foxes certainly have the ammo to pile more misery on Liverpool, but they are also missing some important players and their visitors have been in decent form on the road recently.
> Click here to read our full preview for this match
> How Liverpool could line up against Leicester
> Liverpool injury, suspension list vs. Leicester
Crystal Palace vs. Burnley (Saturday, 3.00pm)
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Both Crystal Palace and Burnley will be looking to return to winning ways in the Premier League when they lock horns at Selhurst Park on Saturday afternoon.
Palace, who lost 2-0 at Leeds United on Monday night, occupy 13th position in the table, while Burnley currently sit 17th but are eight points above the relegation zone heading into the next set of fixtures.
We say: Crystal Palace 1-1 Burnley
There has not actually been a Premier League draw between these two teams since September 2014, but we are finding it difficult to separate them here. Both managers will be wary of losing this fixture, which could create a tense and nervy affair at Selhurst Park.
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Man City vs. Spurs (Saturday, 5.30pm)
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A Tottenham Hotspur team formerly tipped as title contenders are gearing up to meet a Manchester City side who are certainly regarded as the favourites for the big prize now.
The two giants of the English game endured contrasting fortunes in the FA Cup in midweek, with Pep Guardiola's record-breaking Man City easing to a 3-1 win at Swansea while Jose Mourinho's Tottenham lost 5-4 at Everton after extra time.
Spurs came up trumps 2-0 in the first meeting between the clubs earlier in the season, but the visitors find themselves 14 points behind their runaway opponents ahead of this fixture.
We say: Manchester City 2-0 Tottenham Hotspur
These two powerhouses have gone in completely opposite directions since Tottenham's triumph earlier in the campaign, and we expect that to be reflected in the scoreline this weekend. Guardiola's men do have a few more injury concerns to contend with for the weekend, but their plethora of talented players in all areas of the pitch is sure to prove too much for the visitors.
The last thing that Mourinho's side needed before a trip to City was two gruelling hours of action in midweek - especially seeing as they walked away empty-handed - so we cannot see any other result than a 16th triumph on the trot for Man City in this mouthwatering clash.
> Click here to read our full preview for this match
> How Tottenham could line up against Man City
> How Man City could line up against Tottenham
> Tottenham injury, suspension list vs. Man City
> Man City injury, suspension list vs. Tottenham
Brighton vs. Aston Villa (Saturday, 8.00pm)
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Aston Villa will be looking to continue their push towards the European positions in the Premier League table when they travel to the Amex on Saturday afternoon to take on Brighton & Hove Albion.
The visitors are currently ninth in the division, four points behind sixth-placed West Ham United with two games in hand over the Hammers, while Brighton's recent form has allowed them to move away from danger and into 15th position, now 10 points clear of the relegation zone.
We say: Brighton & Hove Albion 1-2 Aston Villa
Brighton's recent form must be respected, and it would not be a surprise to see Potter's side pick up another positive result this weekend. The Seagulls have been disappointing at home, though, and we fancy a talented Villa to secure a vital three points in their pursuit of a European position.