Serie A 2021-22 Head-to-Head
Top Six
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | AC Milan | 10 | 6 | 3 | 1 | 14 | 7 | 7 | 21 |
| 2 | Napoli | 10 | 5 | 2 | 3 | 18 | 12 | 6 | 17 |
| 3 | Inter Milan | 10 | 3 | 5 | 2 | 13 | 13 | 0 | 14 |
| 4 | Atalanta BCAtalanta | 10 | 2 | 5 | 3 | 12 | 15 | -3 | 11 |
| 5 | Juventus | 10 | 1 | 6 | 3 | 9 | 10 | -1 | 9 |
| 6 | Lazio | 10 | 1 | 3 | 6 | 10 | 19 | -9 | 6 |
Bottom Six
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Hellas VeronaHellas Verona | 10 | 6 | 3 | 1 | 21 | 13 | 8 | 21 |
| 2 | Sampdoria | 10 | 5 | 2 | 3 | 15 | 11 | 4 | 17 |
| 3 | SpeziaSpezia | 10 | 5 | 2 | 3 | 12 | 12 | 0 | 17 |
| 4 | Genoa | 10 | 2 | 4 | 4 | 10 | 13 | -3 | 10 |
| 5 | CagliariCagliari | 10 | 2 | 4 | 4 | 11 | 13 | -2 | 10 |
| 6 | VeneziaVenezia | 10 | 0 | 5 | 5 | 8 | 15 | -7 | 5 |
