Salernitana vs. Spezia (Saturday, 2.00pm)
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Separated by just a point in the Serie A standings, Salernitana and Spezia clash at Stadio Arechi on Saturday, seeking to draw themselves further clear of the drop zone.
Despite losing three of their last four games, the hosts sit just above their Ligurian counterparts, as both clubs battle to secure mid-table comfort rather than flirting with relegation again.
We say: Salernitana 2-1 Spezia
Both sides will sense an opportunity to take maximum points, but as Spezia tend to travel so badly, Salernitana's greater goal threat can pay dividends. They have found the net at a rate of nearly two goals per game at the Arechi, so should be able to continue in that vein this weekend.
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AC Milan vs. Monza (Saturday, 5.00pm)
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Contesting a special derby in Serie A for the very first time, champions AC Milan host promoted Monza on Saturday evening.
The Rossoneri's former owners return to San Siro with their side seeking an upset to surpass even last month's win over Juventus; meanwhile, the hosts target three points to stay in touch at the top of the table.
We say: AC Milan 2-0 Monza
Despite signing some experienced heads in the summer, the occasion could prove too much for Monza to handle as they tackle their mighty neighbours. With Milan recovering injured players and having enjoyed a free midweek, expect them to win and stay on Napoli's coat-tails.
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Fiorentina vs. Inter Milan (Saturday, 7.45pm)
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Aiming to sustain their recent resurgence, Inter Milan travel to Stadio Artemio Franchi on Saturday, where they face a Fiorentina side still stuck in neutral after 10 rounds of Serie A.
Though Inter start the weekend eight points adrift of the summit, three wins from their last four matches has reignited their season at home and in Europe. By contrast, the Viola have won just twice in the league and sit in the bottom half of the standings.
We say: Fiorentina 1-2 Inter Milan
Inter have both scored and conceded in all of their last nine Serie A away matches - each game seeing a total of at least three goals scored in the process - and while Fiorentina are a tougher nut to crack on home soil, form suggests an away win is the likeliest outcome at the Franchi this weekend.