John Isner put on a performance of perfect serving as he claimed a straight-sets win over a resilient Frederico Gil.
The USA number two claimed a solitary break in each set and won every one of his 11 service games against the Portuguese.
Isner will now face Juan Monaco in the next round after the Argentine overcame Nicolas Mahut 6-4 5-7 6-3.
The American has never failed to reach the last 64 in his five visits to Indian Wells.
