Wimbledon will finally witness the return of Andy Murray after two years away when he plays in the men's doubles.
There is a fascinating clash in prospect between Rafael Nadal and Nick Kyrgios, while Roger Federer and Serena Williams are both in action.
Here, PA previews the fourth day of action.
Order of play
Centre court
Kei Nishikori v Cameron Norrie
Katerina Siniakova v Johanna Konta
Nick Krygios v Rafael Nadal
Court One
Kristina Mladenovic v Petra Kvitova
Jay Clarke v Roger Federer
Serena Williams v Kaja Juvan
Other courts
Murray/Herbert v Copil/Humbert (TBC)
Dan Evans v Nikoloz Basilashvili (second on Court 2)
Lauren Davis v Angelique Kerber (third on Court 2)
Harriet Dart v Beatriz Haddad Maia (first on Court 12)
Welcome home
After 723 days of injury hell Murray finally gets his long-awaited SW19 return. It may not be in the singles, but the Scot is determined to enjoy every minute of his men's doubles opener as he and partner Pierre-Hugues Herbert take on Marius Copil and Ugo Humbert.
Brit Watch
There are five players trying to put smiles back on the home crowd's faces in the singles after Heather Watson and Kyle Edmund went out on Wednesday. Jay Clarke has a dream encounter with Roger Federer on Court One, Cameron Norrie gets a Centre Court debut against Kei Nishikori, followed by Johanna Konta's clash with Katerinia Siniakova, while Dan Evans takes on Nikoloz Basilashvili on Court Three. Harriet Dart completes the quintet against Beatriz Haddad Maia, first up on Court 12.
Match of the day
There can only be one contender for this, the blockbusting clash between Kyrgios and Nadal, which has quite rightly been given headline billing on Centre Court. There are so many sub-plots to this match, not least the ongoing feud between the two, which has seen a war of words break out in recent months. Nadal will not be keen on playing someone of Kyrgios' ability so early and this is sure to be box office.
Potential upset
After losing Britain's top male player on Wednesday, the women's one could be vulnerable just a day later. Konta is up against Czech world number 38 Siniakova on second. Siniakova beat Naomi Osaka at the French Open, is a doubles champion at SW19 and has defeated Konta in their only previous meeting.