Eerste Divisie 2021-22 Head-to-Head
Top Six
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | VVV-VenloVVV-Venlo | 10 | 7 | 1 | 2 | 21 | 13 | 8 | 22 |
| 2 | NAC BredaNAC Breda | 10 | 5 | 4 | 1 | 19 | 11 | 8 | 19 |
| 3 | FC EindhovenFC Eindhoven | 10 | 5 | 2 | 3 | 12 | 7 | 5 | 17 |
| 4 | Almere CityAlmere City | 10 | 2 | 3 | 5 | 10 | 12 | -2 | 9 |
| 5 | MVV MaastrichtMVV | 10 | 3 | 0 | 7 | 8 | 18 | -10 | 9 |
| 6 | TelstarTelstar | 10 | 1 | 4 | 5 | 10 | 19 | -9 | 7 |
Bottom Six
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | EmmenEmmen | 10 | 8 | 1 | 1 | 17 | 5 | 12 | 25 |
| 2 | SBV ExcelsiorExcelsior | 10 | 7 | 2 | 1 | 23 | 7 | 16 | 23 |
| 3 | FC VolendamVolendam | 10 | 5 | 2 | 3 | 20 | 18 | 2 | 17 |
| 4 | Den BoschDen Bosch | 10 | 3 | 1 | 6 | 10 | 22 | -12 | 10 |
| 5 | Dordrecht | 10 | 2 | 3 | 5 | 17 | 21 | -4 | 9 |
| 6 | Jong FC UtrechtJong Utrecht | 10 | 0 | 1 | 9 | 4 | 18 | -14 | 1 |
