David Moyes has decided to pair Ryan Giggs and Phil Jones in midfield for tonight's clash with Bayer Leverkusen.
That means Shinji Kagawa, Nani and Antonio Valencia will play behind Wayne Rooney.
Nemanja Vidic is missing, so Jonny Evans and Rio Ferdinand are tonight's centre-backs.
Leverkusen have Gonzalo Castro playing behind striker Stefan Kiessling and Emre Can filling in at left-back.
Lars Bender, Stefan Reinartz and captain Simon Rolfes make up the home side's midfield.
Bayer Leverkusen: Leno; Can, Spahic, Donati, Toprak; Reinartz, Rolfes, Bender; Son, Castro; Kiessling
Manchester United: De Gea; Smalling, Ferdinand, Evans, Evra; Giggs, Jones; Valencia, Kagawa, Nani; Rooney
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