Here, Press Association Sport takes a look back at some memorable moments from previous ties between the two clubs down the years.
Former United striker Danny Welbeck (right) marked his return to Old Trafford with what proved to be the winning goal in the 2015 FA Cup sixth-round tie (Martin Rickett/PA Images)
England forward Wayne Rooney (left) was on target as United knocked the Gunners out of the FA Cup to reach the semi-finals in 2011 (Martin Rickett/PA Images)
Arsenal defender Emmanuel Eboue was sent off at Old Trafford during the 2008 FA Cup fifth-round tie (Martin Rickett/PA Images)
Arsenal captain Patrick Vieira scored the winning penalty as United were beaten in a shoot-out after the 2005 FA Cup final in Cardiff had ended goalless (Rebecca Naden/PA Archive)
Paul Scholes (second left) was on target in the 2004 semi-final at Villa Park as United ended Arsenal's hopes of a third successive FA Cup triumph (Rui Vieira/PA Archive)
A dramatic extra-time winner from Ryan Giggs, who pulled off his shirt, in the 1999 FA Cup semi-final replay at Villa Park sparked wild celebrations on and off the pitch (David Jones/PA Archive)
A 17-year-old Norman Whiteside was on target as United beat Arsenal 2-1 in the 1983 FA Cup semi-final at Villa Park (PA Archive)
Manchester United manager Ron Atkinson joined in with the post-match celebrations (PA Archive/PA Images)
Manchester United boss Dave Sexton (in suit on right) and Terry Neill lead their teams out at Wembley for a memorable 1979 FA Cup final, which the Gunners won 3-2 (PA Archive/PA Images)
Alan Sunderland slid in to score a dramatic last-minute winner in the 1979 FA Cup final, after United had just fought back from 2-0 down (PA Archive/PA Images)
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