Sassuolo vs. Inter Milan (Saturday, 2.00pm)
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Soon after a form-defying triumph in Europe, Inter Milan return to domestic duty on Saturday, as they visit mid-table Sassuolo.
Having beaten Barcelona in the Champions League, the Nerazzurri now aim to recover from a sluggish start in Serie A, which sees them only level on points with their hosts.
We say: Sassuolo 1-2 Inter Milan
Lifted not only by a positive result in Europe, but also the steadfast manner in which it was achieved, Inter can overcome their recent woes away from San Siro and earn three valuable points. Sassuolo held Milan goalless last month, but will come up short against their Nerazzurri rivals.
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AC Milan vs. Juventus (Saturday, 5.00pm)
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A tussle between two of Serie A's heavyweight title contenders sees champions AC Milan welcome Juventus to San Siro on Saturday evening.
Having experienced very different fates in Europe this week, the sides convene in Italy's second city separated by four points and two places in the standings, with the hosts currently holding the upper hand.
We say: AC Milan 1-1 Juventus
Milan and Juventus are two of the three teams to have lost the fewest Serie A matches in 2022 - and they could not be split in either of their meetings last term.
Only twice before have they drawn three times in a row, but such a result could be on the cards as the champions are still weakened by numerous injuries.
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Bologna vs. Sampdoria (Saturday, 7.45pm)
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After pulling the plug on their coach after another setback last week, Sampdoria travel to Stadio Renato Dall'Ara on Saturday, where they take on fellow strugglers Bologna.
While Samp remain winless, and therefore rooted to the foot of the Serie A standings, their hosts have already made a managerial change of their own - but to little effect so far.
We say: Bologna 1-2 Sampdoria
While no team has conceded more first-half goals than Sampdoria in Serie A this season (nine), Bologna have leaked the same number in the second - so both sides have the opportunity to boost a meagre tally this weekend.
Neither is fully familiar with their new coach's demands, so a disjointed affair could be decided by one moment of magic or a minor disaster.