The 33-year-old is suffering from a hamstring injury which had seen him struggling ahead of the first leg two weeks ago.
According to reports in Spain, Xavi is unlikely to be fit for the return leg at the Camp Nou on March 12.
Blaugrana must overcome a 2-0 deficit if they are to reach the quarter-finals.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Barcelona | 14 | 11 | 1 | 2 | 42 | 14 | 28 | 34 |
| 2 | Atletico MadridAtletico | 14 | 8 | 5 | 1 | 21 | 8 | 13 | 29 |
| 3 | Real Madrid | 12 | 8 | 3 | 1 | 25 | 11 | 14 | 27 |
| 4 | Villarreal | 13 | 7 | 4 | 2 | 25 | 21 | 4 | 25 |
| 5 | Osasuna | 14 | 6 | 4 | 4 | 19 | 22 | -3 | 22 |
| 6 | GironaGirona | 14 | 6 | 3 | 5 | 20 | 18 | 2 | 21 |
| 7 | Mallorca | 14 | 6 | 3 | 5 | 13 | 12 | 1 | 21 |
| 8 | Athletic Bilbao | 13 | 5 | 5 | 3 | 19 | 13 | 6 | 20 |
| 9 | Real BetisBetis | 14 | 5 | 5 | 4 | 16 | 16 | 0 | 20 |
| 10 | Real Sociedad | 13 | 5 | 3 | 5 | 11 | 10 | 1 | 18 |
| 11 | Celta Vigo | 14 | 5 | 3 | 6 | 22 | 24 | -2 | 18 |
| 12 | Sevilla | 14 | 5 | 3 | 6 | 13 | 18 | -5 | 18 |
| 13 | Rayo Vallecano | 13 | 4 | 4 | 5 | 13 | 14 | -1 | 16 |
| 14 | Leganes | 13 | 3 | 5 | 5 | 13 | 16 | -3 | 14 |
| 15 | Getafe | 14 | 2 | 7 | 5 | 10 | 11 | -1 | 13 |
| 16 | AlavesAlaves | 14 | 4 | 1 | 9 | 15 | 24 | -9 | 13 |
| 17 | Las PalmasLas Palmas | 14 | 3 | 3 | 8 | 18 | 25 | -7 | 12 |
| 18 | Valencia | 12 | 2 | 4 | 6 | 12 | 19 | -7 | 10 |
| 19 | Espanyol | 13 | 3 | 1 | 9 | 12 | 26 | -14 | 10 |
| 20 | Real ValladolidValladolid | 14 | 2 | 3 | 9 | 10 | 27 | -17 | 9 |
| > La Liga Full Table | |||||||||
