North London meets West London in Monday's headline Premier League fixture, as Tottenham Hotspur pit their wits against Chelsea.
The Lilywhites maintained a two-point lead at the top of the table owing to a 2-1 win over Crystal Palace last Friday, as a Joel Ward own goal and Son Heung-min strike did the damage before Jordan Ayew's consolation.
At the same time, Ange Postecoglou set a new record of 26 points from his opening 10 games as a Premier League manager, and Monday's London derby will see Mauricio Pochettino reunite with his former employers.
Here, Sports Mole rounds up Spurs' latest injury and suspension news ahead of their clash with Chelsea, who overcame Blackburn Rovers 2-0 in EFL Cup action in midweek.
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Status: Minor doubt
Type of issue: Muscle
Possible return date: November 6 (vs. Chelsea)
Destiny Udogie sustained a muscular problem against Fulham last month, and having been unable to contribute to the win over Palace, the Italy international will need a once-over ahead of Monday's game.
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Status: Major doubt
Type of issue: Ankle
Possible return date: November 6 (vs. Chelsea)
Ben Davies started the win over Palace in place of Udogie, but the Welshman then had to be replaced at the break after taking a blow to the ankle, and Postecoglou has admitted that he is unlikely to make the cut on Monday.
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Status: Out
Type of injury: Knee
Possible return date: Unknown
Ivan Perisic may have played his final game in a Tottenham jersey, having undergone an operation on an ACL injury in September, which will likely rule the Croatian out for the season.
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Status: Out
Type of injury: Knee
Possible return date: Unknown
Manor Solomon has also had to go under the knife to address a knee injury, but the Israel international could aim for a return to first-team action in January.
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Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ryan Sessegnon remains on the road to recovery from the hamstring injury he underwent an operation on in the summer, and there is currently no indication when the Englishman might return.
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Status: Out
Type of injury: Ankle
Possible return date: Unknown
Backup goalkeeper Alfie Whiteman also required a procedure to correct an ankle injury in August, and as is the case with Sessegnon, it is unclear when the 25-year-old might be back in action.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Tottenham Hotspur have no suspended players for this match.
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