Wimbledon champion Angelique Kerber gets her defence up and running against Tatjana Maria on Tuesday.
The likes of Roger Federer, Rafael Nadal, Ashleigh Barty and Serena Williams are also in action.
Johanna Konta is one of eight Brits who are looking to follow Kyle Edmund and Heather Watson into the second round.
Here, PA previews the second day of action.
Order of play
Centre court
Tatjana Maria v Angelique Kerber
Lloyd Harris v Roger Federer
Serena Williams v Giulia Gatto-Monticone
Court One
Ashleigh Barty v Saisai Zheng
Ana Bogdan v Johanna Konta
Yuichi Sugita v Rafael Nadal
Other courts
Sloane Stephens v Timea Bacsinszky (Court Two)
Dominic Thiem v Sam Querrey (Court Two)
Maria Sharapova vs Pauline Parmentier (Court Two)
Ons Jabeur vs Petra Kvitova (Court Three)
Brits Watch
With Watson and Edmund winning on Monday, the attention turned to the other eight Brits in action on day two. British number one Konta kicks off her championships against Ana Bogdan of Romania, second on Court One. Katie Swan meets Laura Siegemund of Germany and Harriet Dart is up against American Christina McHale. Of the British men in action Cameron Norrie plays Denis Istomin of Uzbekistan, Dan Evans faces Argentinian Federico Delbonis, James Ward meets Georgia's Nikoloz Basilashvili and Jay Clarke takes on American Noah Rubin. In the evening all eyes will be on Paul Jubb, the 19-year-old from Hull who wonĀ the prestigiousĀ NCAA singles title, when he tackles Joao Sousa of Portugal.
Match of the day
It may not have got top billing on a day when Roger Federer, Rafael Nadal, Serena Willams, Angelique Kerber and Maria Sharapova are all playing but the match between Donna Vekic and Alison Riske should be keenly contested. Both women are proficient grass-court players, which the seeded Croatian will be favourite to come through.
Potential upsets
Dominic Thiem, seeded fifth, was handed a tough draw against 2016 semi-finalist Sam Querrey and it could leave him vulnerable. The Austrian has not played since his French Open final defeat to Rafael Nadal, while the big-serving American got to the final at Eastbourne last week.