Marco Reus will play no part in Germany's upcoming Euro 2016 qualifiers after he suffered a toe injury in training.
The Borussia Dortmund star has had an injury-stricken few years, having suffered ankle ligament damage twice in 2014.
Reus, who missed Germany's World Cup-winning campaign, has not played for his nation since September last year.
The 26-year-old started the Bundesliga season strongly by scoring two goals in three games, but his run has been halted with a fresh injury.
Germany will take on Poland on Friday before facing Scotland at Hampden Park three days later.