Napoli vs. Spezia (Saturday, 2.00pm)
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After drawing global admiration for their midweek heroics in Europe, Napoli return to domestic duty on Saturday, as they host Spezia at Stadio Maradona.
A spectacular showing in the 4-1 defeat of Liverpool got the Azzurri's Champions League campaign off to a perfect start, and they now take on a side who have struggled in Serie A since the opening day.
We say: Napoli 2-0 Spezia
Balancing duties at home and abroad will prove a tough task for Napoli, but given their visitors' current form and their own increasing squad depth, they are set to secure a third straight victory - and their first top-flight win over Spezia at the Maradona.
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Inter Milan vs. Torino (Saturday, 5.00pm)
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After a week to forget at home and abroad, Inter Milan aim to bounce back against Torino on Saturday evening, in their third straight game at San Siro.
Beaten in both the Derby della Madonnina and their Champions League opener over the past few days, the Nerazzurri now welcome an improving away side to Milan.
We say: Inter Milan 2-1 Torino
Remarkably, only rock-bottom Monza have conceded more goals than Inter in the second half of Serie A matches this season, so even if they can break down obdurate opponents, they may not have it their own way until the final whistle. By the finest of margins, though, the hosts should find a way to take all three points.
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Sampdoria vs. AC Milan (Saturday, 7.45pm)
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After an eventful week at home and abroad, AC Milan resume their Scudetto defence on Saturday evening, as they visit Sampdoria at Stadio Luigi Ferraris.
Just days after tasting sweet success in the Milan Derby, the Rossoneri were held to a draw in their first European encounter of the season, and they now meet a side struggling at the wrong end of the Serie A standings.
We say: Sampdoria 0-2 AC Milan
Although recovering quickly from their midweek exertions may be a challenge for Milan, they are fortunate their opponents are drained of confidence and lack a goalscoring threat. Pioli can therefore make use of his deepening squad to continue his side's unbeaten start.