David Alaba, Dani Carvajal, Aurelien Tchouameni, Lucas Vazquez and Ferland Mendy will all miss Real Madrid's La Liga contest with Real Sociedad on Sunday night.
Vazquez remains unavailable for selection due to an ankle injury, while Mendy is out with the thigh problem that he suffered against Atletico Madrid in the Copa del Rey on Thursday night.
Return dates for the duo have not been set, but Real Madrid head coach Carlo Ancelotti revealed during his press conference on Saturday that Alaba, Carvajal and Tchouameni should be back for the league contest with Valencia next week.
"He will be available for the next game, as will Alaba and Tchouameni, who will be back on Thursday against Valencia," said Ancelotti when asked for an update on Carvajal, with the Spaniard recently being unavailable for selection due to a muscular issue.
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Rodrygo had also emerged as a doubt due to the Achilles problem that he picked up against Atletico, but the Brazilian has been named in the squad.
Meanwhile, there is also a return for Eden Hazard, with the Belgium international recovering from an ankle injury to make himself available for selection.
Real Madrid's defensive absentees could potentially lead to Eduardo Camavinga starting at left-back, with Nacho widely expected to continue at right-back for the Spanish and European champions.
"It will be a tough match, we have to play a complete game defensively and offensively. The aim is to do better than we did in the first half against Atletico Madrid," said Ancelotti during his press conference.
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"What happens in football goes through my head. There are moments of difficulty and you have to keep a cool head and that's what we have done.
"This is a team effort and everyone brings their own contribution. Football gives you the chance to quickly get out of a bad moment and that's why you always have to be focused."
Real Madrid booked their spot in the semi-finals of the Copa del Rey with a 3-1 victory over Atletico on Thursday, and they will be bidding to make it back-to-back league wins on Sunday, having beaten Athletic Bilbao 2-0 in their last fixture in Spain's top flight.
Real Madrid squad vs. Real Sociedad:
Courtois, Lunin, Lopez; Militao, Vallejo, Nacho, Odriozola, Rudiger; Kroos, Modric, Camavinga, Valverde, Ceballos, Martin; Hazard, Benzema, Asensio, Vinicius, Rodrygo, Mariano
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