Premier League 2 - Div 2 2021-22 Head-to-Head
Top Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Fulham Under-23sFulham U23s | 10 | 8 | 2 | 0 | 27 | 9 | 18 | 26 |
| 2 | Newcastle United Under-23sNewcastle U23s | 10 | 6 | 0 | 4 | 20 | 20 | 0 | 18 |
| 3 | Burnley Under-23sBurnley U23s | 10 | 5 | 1 | 4 | 20 | 17 | 3 | 16 |
| 4 | Aston Villa Under-23sVilla U23s | 10 | 3 | 2 | 5 | 16 | 17 | -1 | 11 |
| 5 | Birmingham City Under-23sBirmingham U23s | 10 | 2 | 2 | 6 | 14 | 21 | -7 | 8 |
| 6 | Middlesbrough Under-23sBoro U23s | 10 | 2 | 1 | 7 | 10 | 23 | -13 | 7 |
Bottom Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Southampton Under-23sSaints U23s | 10 | 6 | 1 | 3 | 14 | 13 | 1 | 19 |
| 2 | Stoke City Under-23sStoke U23s | 10 | 4 | 5 | 1 | 18 | 10 | 8 | 17 |
| 3 | Wolverhampton Wanderers Under-23sWolves U23s | 10 | 4 | 2 | 4 | 18 | 18 | 0 | 14 |
| 4 | Sunderland Under-23sSunderland U23s | 10 | 4 | 1 | 5 | 14 | 13 | 1 | 13 |
| 5 | West Bromwich Albion Under-23sWest Brom U23s | 10 | 2 | 4 | 4 | 8 | 14 | -6 | 10 |
| 6 | Reading Under-23sReading U23s | 10 | 2 | 3 | 5 | 12 | 16 | -4 | 9 |
