England manager Gareth Southgate has handed Marc Guehi and Kyle Walker-Peters their debuts for Saturday's friendly with Switzerland at Wembley.
With both Reece James and Trent Alexander-Arnold pulling out due to injury, Walker-Peters is handed his first senior international start amid England's lack of right-back options.
Meanwhile, Guehi starts alongside Conor Coady and John Stones in a back three, with Southgate seemingly handing several fringe and young players a chance to stake their claims for World Cup spots.
Undisputed number one Jordan Pickford takes his place in goal, with Harry Maguire and Ben White both occupying spots on the bench, and Luke Shaw gets the nod on the left-hand side.
Conor Gallagher also makes just his second appearance and first start for England alongside Jordan Henderson in midfield, with Jude Bellingham and Declan Rice among the substitutes.
Phil Foden and Mason Mount occupy spots slightly further forward alongside Harry Kane, who needs one more strike to equal Bobby Charlton's 49 goals for the Three Lions.
England starting lineup: Pickford; Coady, Stones, Guehi; Walker-Peters, Henderson, Gallagher, Shaw; Mount, Foden; Kane
Substitutes: Pope, Forster, Maguire, White, Mings, Mitchell, Rice, Bellingham, Ward-Prowse, Sterling, Grealish, Watkins
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